San Francisco, CA - New results from three trials comparing off-pump and on-pump CABG have not been able to make a definitive case that off-pump is better for high-risk patients, despite that still being the belief of all the surgeons leading the studies.
The three trials were presented here today at the late-breaking clinical-trials session at the American College of Cardiology (ACC) 2013 Scientific Sessions. Two trials have also been published online today in the New England Journal of Medicine [1,2].
Two large-scale studies—first results from the German Off-Pump CABG in Elderly Trial (GOPCABE) and 12-month results from the CORONARY study—showed similar findings with nonsignificant differences between the two procedures at 30 days and 12 months. A third, much smaller, single-center Czech study—PRAGUE-6—did show a benefit of off-pump, but with only 200 patients, it is difficult to draw conclusions from these data.